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Curcumin (Curcuma longa) has as its main therapeutic substance, diferuloyl methane. Curcumin is derived from turmeric, a plant that belongs to the ginger family. Both laboratory as well as epidemiological studies has shown that curcumin has a multitude of anticancer effects.

Turmeric is a spice that is grown in many Asian countries and is also known as Indian saffron, jiang huang, haridra and haldi. The main culinary product is curcumin powder, which has been used not only as a food condiment in Asian cuisine but also in all of the traditional medical disciplines throughout the world, including Ayurveda and Traditional Chinese Medicine (TCM).

Research has been able to show that there are quite low rates of cancer in countries where people regularly eat 100mg to 200mg a day over long periods of time.

Over 2,000 published studies have shown curcumin is effective against cancers of the breast, prostate, liver, colon, lung, pancreas and more. Many of these studies have shown curcumin actually stops cancer cells from dividing, causes them to “commit suicide”, prevents spread (metastases) and stops them from forming in the first place.

And, the benefit of this substance is that curcumin has the ability to kill cancer cells while leaving healthy cells unharmed, and is even protective. This is in broad contrast to chemotherapy, which destroys all cells, healthy and cancer cells.

Curcumin Kills Cancer in Multiple Ways

Curcumin changes both gene activity and expression and thereby not only destroys cancer cells but it promotes healthy cell function. In addition, it has anti-angiogenic properties, which prevent new blood vessels from forming so that the cancer cells cannot grow or spread.

Curcumin affects over 100 molecular pathways once it gets into the cell resulting in the following:

  • Stops the growth and spread of tumor cells
  • Stops healthy cells from becoming cancer cells Able to stop mutated cells so that they cannot spread.
  • Decreases inflammation, which is how cancer stem cells spread and set up “camp”
  • Blocks the proteins necessary to form tumors.
  • Stops new blood vessels from forming

Scientific Explanation

Curcumin physically binds to approximately 33 different proteins, including thioredoxin reductase, cyclooxygenase-2, (COX2), protein kinase C, 5-lipoxygenase (5-LOX), and tubulin. Various molecular targets acted upon by curcumin include transcription factors, growth factors and their receptors, cytokines, enzymes, and genes regulating cell proliferation, and apoptosis.

Curcumin has been shown to inhibit the proliferation (growth and spread) as well as the survival of almost all types of tumor cells.  Scientific evidence has been found to show that the mode of curcumin-induced cell death is a result of both the activation of cell death pathways in cells and by the inhibition of growth/proliferation pathways.

Chatchai Sribundit, M.D.

Dr. Chatchai Sribundit is the distinguished founder of Akesis Life. His education, training and community support is highly regarded worldwide. Dr. Chatchai traveled extensively during the past two decades in order to bring the best possible integrative cancer treatments to Thailand. His primary concern is the well-being of his patients through kindness and care.

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